NMR-Based Metabolomics Analysis of Leptomeningeal Carcinomatosis
نویسندگان
چکیده
منابع مشابه
An NMR metabolomics approach for the diagnosis of leptomeningeal carcinomatosis
Leptomeningeal carcinomatosis (LC) is the third most common metastatic complication of the central nervous system. However, the current modalities to reliably diagnose this condition are not satisfactory. Here we report a preclinical proof of concept for a metabolomics-based diagnostic strategy, using a rat LC model incorporating glioma cells that stably expressed green fluorescent protein. Cyt...
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Leptomeningeal carcinomatosis (LC) is a metastatic cancer invading the central nervous system (CNS). We previously reported a metabolomic diagnostic approach as tested on an animal model and compared with current modalities. Here, we provide a proof of concept by applying it to human LC originating from lung cancer, the most common cause of CNS metastasis. Cerebrospinal fluid from LC (n = 26) a...
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Leptomeningeal carcinomatosis (LC) is the thirdmost commonmetastatic complication of the central nervous system. However, the current modalities to reliably diagnose this condition are not satisfactory. Here, we report a preclinical proof of concept for a metabolomics-based diagnostic strategy using a rat LC model incorporating glioma cells that stably express green fluorescent protein. Cytolog...
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Treatment of Leptomeningeal carcinomatosis (LMC) from solid cancers has not advanced noticeably since the introduction of intra-cerebrospinal fluid (CSF) chemotherapy in the 1970's. The marginal survival benefit and difficulty of intrathecal chemotherapy injection has hindered its wide spread use. Even after the introduction of intraventricular chemotherapy with Ommaya reservoir, frequent devel...
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ژورنال
عنوان ژورنال: Neurosurgery
سال: 2014
ISSN: 0148-396X
DOI: 10.1227/neu.0000000000000517